Human bone marrow core biopsy. - Credit: Gabriel Caponetti

Disorders of the blood and bone marrow are of great public health significance. During development and in the adult bone marrow, a relatively small number of critical transcription factors promote complex and diverse cellular processes to bring about faithful and timely hematopoiesis. The mechanisms by which these factors interface with chromatin to modulate gene expression, and the  partner factors that are critical for this function, are the primary research focus of the Matson Laboratory.